The story is about a Filipino-Chinese family whose members all had to deal with depression. After their parents died, Jimmy (Piolo Pascual) took care of his younger sisters: Anette, (Andrea del Rosario)a closet lesbian yearning to be with her girlfriend; Claire, (Dimples Romana) an abused and neglected wife; and Leslie (Krista Ranillo) a call center agent who denounces the Chinese tradition of having a Filipino boyfriend. Jimmy, however, got so depressed when his wife-to-be eloped with her Filipino boyfriend. This experience prompted him to isolate and confine himself inside his room for six months. His sisters even prepared a cake for him during his birthday but he never came out of his room.
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